Association between Light-Intensity and Moderate-to-Vigorous-Intensity Physical Activity Habits and Kidney Dysfunction: A General Population Cohort Study

Few studies have considered physical activity (PA) intensity and frequency in relation to kidney dysfunction. This study aimed investigate the association of regular light intensity, occasional moderate-to-vigorous activities, their combination with function general population. community-based historical cohort included Japanese people aged ≥40 years. Participants were divided into four groups according PA habits: inactive group (neither light-intensity (LPA) nor (MVPA)), LPA (1.5–3.0 metabolic equivalents (METs) for at least 60 min a day), MVPA (>3.0 METs 30 twice week), + (combination MVPA). The primary outcome was 40% decrease estimated glomerular filtration rate from baseline. Cox proportional hazards model used examine between habits function. In total, 72,999 participants this study. During mean follow-up period 5.9 years, 2,989 (4.1%) achieved outcome. Compared neither MVPA, adjusted hazard ratios 0.94 (95% confidence interval (CI), 0.85–1.03; p = 0.182 ) alone, 0.97 CI, 0.85–1.10; id="M2"> 0.618 0.83 0.76–0.91; id="M3"> < 0.001 MVPA. There significant interaction sex habit ( id="M4"> 0.015 ). Generally, combined associated lower risk dysfunction than lack PA. Future are required determine duration protect